Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
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United States of America Patent
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Feb 22, 2005
Grant Date -
Dec 11, 2003
app pub date -
Jun 4, 2001
filing date -
Jun 4, 2001
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Abstract
A non-polydispersed mixture of conjugates in which each conjugate in the mixture comprises a drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may result in less inter-subject variability than polydispersed mixtures of similar conjugates.
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