Cyclic depsipeptides and drugs containing the same as the active ingredient

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United States of America Patent

PATENT NO 6858585
SERIAL NO

09147434

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Abstract

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Cyclic depsipeptides represented by the formula ##STR1## wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15-carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1, or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.

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Patent Owner(s)

Patent OwnerAddress
NISSHIN SEIFUN GROUP INC25 KANDA-NISHIKI-CHO 1-CHOME CHIYODA-KU TOKYO 101-8441

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hiramoto, Shigeru Saitama-ken, JP 18 194
Kawamura, Koji Saitama-ken, JP 139 947
Kinoshita, Nobuhiro Saitama-ken, JP 36 404
Oshida, Norio Saitama-ken, JP 14 211
Shingai, Akiko Saitama-ken, JP 8 52
Suzuki, Masashi Saitama-ken, JP 202 1793
Takasu, Masako Saitama-ken, JP 7 46
Yanai, Makoto Saitama-ken, JP 24 300
Yasuda, Orie Saitama-ken, JP 7 46

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