Stabilization of implantable bioprosthetic devices
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United States of America Patent
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Mar 1, 2005
Grant Date -
Jun 27, 2002
app pub date -
Aug 22, 2001
filing date -
Apr 27, 1999
priority date (Note) -
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Abstract
The invention relates to methods of stabilizing glycosaminoglycans in a biological tissue (e.g. a bioprosthetic implant) in conjunction with cross-linking of protein in the tissue. The methods of the invention improve the mechanical integrity of the device and improves its stability in vivo. The invention also includes biological tissues having stabilized glycosaminoglycans and cross-linked proteins and kits for preparing such tissues.
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