Nucleosidic and non-nucleosidic folate conjugates
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United States of America Patent
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Mar 1, 2005
Grant Date -
Apr 25, 2002
app pub date -
Oct 9, 2001
filing date -
Oct 24, 1991
priority date (Note) -
Expired
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Abstract
Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2'-, 3'-, 5'-, nucleobase and internucleotide linkage sites. The folate can be attached via the .alpha.- or .gamma.-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed. Also disclosed are nucleosidic and non-nucleosidic linkers conjugated to folic acid and related folates.
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