Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
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United States of America Patent
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Mar 15, 2005
Grant Date -
May 1, 2003
app pub date -
Sep 5, 2002
filing date -
Feb 15, 2001
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Abstract
Pharmaceutical compositions that include an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component are present in a weight-to-weight ratio of between 1:5 and 5:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
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