Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages

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United States of America Patent

PATENT NO 6867294
SERIAL NO

09438989

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Abstract

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Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5', and the 3'-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.

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Patent Owner(s)

Patent OwnerAddress
IONIS PHARMACEUTICALS INC2855 GAZELLE COURT CARLSBAD CA 90210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Manoharan, Muthiah Carlsbad, CA 491 18658
Sanghvi, Yogesh S Encinitas, CA 37 5483

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