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Abstract

A reagent having the general formula of General Formula I: ##STR1## wherein group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with a biologically active species; group R.sub.2 is one of H and OH moieties; group R.sub.3 is one of an alkyl and a methylene bearing an electronegative substituent; group Z is one of (CH.sub.2).sub.n and CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.n.sub..sub.2 , and n is an integer of from 1 to 5, and n.sub.2 is an integer of from 1 to 4; and each of group Z.sub.2 and Z.sub.3 are (CH.sub.2)CONH(CH.sub.2).sub.3 CONH(CH.sub.2).sub.2. Also, a reagent having the general formula of General Formula II: ##STR2## group R.sub.2 is one of H and OH moieties; group Z is one of (CH.sub.2).sub.n and CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.n.sub..sub.2 , and n is an integer of from 1 to 5, and n.sub.2 is an integer of from 1 to 4; each of group Z.sub.2 and group Z.sub.3 include one of (CH.sub.2)CONH(CH.sub.2).sub.3 CONH(CH.sub.2).sub.2 ; and (CH.sub.2)CONH(CH.sub.2); and group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with the biologically active species.

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