Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
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United States of America Patent
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Apr 5, 2005
Grant Date -
Apr 1, 2004
app pub date -
Jul 8, 2003
filing date -
Jul 9, 2002
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Abstract
Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure ##STR1## wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH.sub.2).sub.x where x is 1 to 5, or A is (CH.sub.2).sub.x.sup.1 where x.sup.1 is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is --(CH.sub.2).sub.x.sup.2 --O--(CH.sub.2).sub.x.sup.3 -- where x.sup.2 is 0 to 5 and x.sup.3 is 0 to 5, provided that at least one of x.sup.2 and x.sup.3 is other than 0; B is a bond or is (CH.sub.2).sub.x.sup.4 where x.sup.4 is 1 to 5; X is CH or N; X.sub.2 is C, N, O or S; X.sub.3 is C, N, O or S; X.sub.4 is C, N, O or S; X.sub.5 is C, N, O or S; X.sub.6 is C, N, O or S; and A, R.sup.1, R.sup.2, R.sup.2a, R.sup.2b, R.sup.2c, R.sup.3 and Y are as defined herein.
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