US Patent No: 6,884,407
Number of patents in Portfolio can not be more than 2000
Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
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Apr 26, 2005
Issued date -
May 18, 2000
filing date -
09/573,265
serial no -
In Force
status
Importance
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Abstract
Improved methods for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combination with a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.
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First Claim
Related Publications
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International Classification(s)
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- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,844,882 Concentrated stabilized microbubble-type ultrasonic imaging agent | 213 | 1987 | |
| 5,409,688 Gaseous ultrasound contrast media | 164 | 1992 | |
| 5,558,855 Phase shift colloids as ultrasound contrast agents | 97 | 1993 | |
| 5,393,524 Methods for selecting and using gases as ultrasound contrast media | 159 | 1993 | |
| 5,529,766 Contrast agents | 88 | 1993 | |
| 5,536,490 Contrast agents | 97 | 1993 | |
| 5,595,723 Method for preparing storage stable colloids | 76 | 1993 | |
| 5,558,853 Phase shift colloids as ultrasound contrast agents | 136 | 1994 | |
| 5,562,893 Gas-filled microspheres with fluorine-containing shells | 82 | 1994 | |
| 5,558,856 Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging | 129 | 1994 | |
| 5,573,751 Persistent gaseous bubbles as ultrasound contrast media | 74 | 1994 | |
| 5,558,854 Ultrasound contrast media comprising perfluoropentane and perfluorohexane gas | 99 | 1995 | |
| 5,558,094 Methods for using persistent gases as ultrasound contrast media | 92 | 1995 | |
| 5,614,169 Contrast agents, consisting of galactose particles and an amphilic carboxylic acid | 58 | 1995 | |
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| 5,676,928 Liposomes | 78 | 1995 | |
| 5,707,606 Phase shift colloids as ultrasound contrast agents | 52 | 1995 | |
| 5,707,607 Phase shift colloids as ultrasound contrast agents | 56 | 1995 | |
| 5,976,501 Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion | 27 | 1996 | |
| 6,331,289 Targeted diagnostic/therapeutic agents having more than one different vectors | 51 | 1997 | |
| 6,261,537 Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors | 83 | 1997 | |
| 6,159,445 Light imaging contrast agents | 134 | 1997 | |
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| 5,230,882 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 89 | 1992 | |
| 5,352,435 Ionophore containing liposomes for ultrasound imaging | 116 | 1992 | |
| 5,281,408 Low density microspheres and their use as contrast agents for computed tomography | 136 | 1993 | |
| 5,305,757 Gas filled liposomes and their use as ultrasonic contrast agents | 93 | 1993 | |
| 5,469,854 Methods of preparing gas-filled liposomes | 165 | 1993 | |
| 5,334,381 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 169 | 1993 | |
| 5,456,900 Low density microspheres and their use as contrast agents for computed tomography | 65 | 1993 | |
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| 5,711,933 Method of making polymeric gas or air filled microballoons for ultrasonic echography | 89 | 1994 | |
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| 5,578,292 Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof | 74 | 1995 | |
| 5,567,414 Stable microbubbles suspensions injectable into living organisms | 92 | 1995 | |
| 5,643,553 Stable microbubbles suspensions injectable into living organisms | 94 | 1995 | |
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| 5,605,673 Stabilized microbubble compositions for ultrasound | 95 | 1994 | |
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| 5,639,443 Stabilized microbubble compositions | 92 | 1995 | |
| 5,626,833 Ultrasound imaging method using microbubbles | 65 | 1995 | |
| 5,804,162 Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients | 50 | 1995 | |
| 5,733,527 Methods for harmonic imaging with ultrasound | 60 | 1996 | |
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| 5,498,421 Composition useful for in vivo delivery of biologics and methods employing same | 209 | 1994 | |
| 5,508,021 Non-fluorinated polymeric shells for medical imaging | 86 | 1994 | |
| 5,505,932 Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging | 125 | 1995 | |
| 5,512,268 Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof | 86 | 1995 | |
| 5,639,473 Methods for the preparation of nucleic acids for in vivo delivery | 82 | 1995 | |
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| 5,209,720 Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes | 116 | 1991 | |
| 5,358,702 Methoxylated gel particle contrast media for improved diagnostic imaging | 75 | 1993 | |
| 5,736,121 Stabilized homogenous suspensions as computed tomography contrast agents | 28 | 1995 | |
| 5,874,062 Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents | 34 | 1995 | |
| 5,997,898 Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery | 22 | 1995 | |
|
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| 5,514,720 Stable emulsions of highly fluorinated organic compounds | 17 | 1988 | |
| 5,350,571 Emulsions of highly fluorinated organic compounds | 79 | 1992 | |
| 5,571,498 Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI). | 27 | 1994 | |
| 5,635,539 Stable emulsions of highly fluorinated organic compounds | 20 | 1996 | |
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| 4,737,323 Liposome extrusion method | 185 | 1986 | |
| 4,781,871 High-concentration liposome processing method | 119 | 1986 | |
| 4,895,719 Method and apparatus for administering dehydrated liposomes by inhalation | 270 | 1987 | |
| 5,013,556 Liposomes with enhanced circulation time | 453 | 1989 | |
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| 4,921,706 Unilamellar lipid vesicles and method for their formation | 114 | 1984 | |
| 4,898,734 Polymer composite for controlled release or membrane formation | 185 | 1988 | |
| 4,893,624 Diffuse focus ultrasound hyperthermia system | 116 | 1988 | |
| 5,565,215 Biodegradable injectable particles for imaging | 95 | 1994 | |
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| 4,420,442 Manufacturing process for hollow microspheres | 106 | 1982 | |
| 4,421,562 Manufacturing process for hollow microspheres | 93 | 1983 | |
| 4,549,892 Process for producing hollow, bilayered silicate microspheres | 65 | 1983 | |
| 4,540,629 Hollow microspheres with organosilicon-silicate walls | 78 | 1984 | |
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| 5,149,319 Methods for providing localized therapeutic heat to biological tissues and fluids | 174 | 1990 | |
| 5,558,092 Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously | 279 | 1995 | |
| 5,770,222 Therapeutic drug delivery systems | 171 | 1995 | |
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| 5,785,950 Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of making and using them | 21 | 1994 | |
| 5,502,094 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use | 59 | 1995 | |
| 5,567,765 Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods of use | 70 | 1996 | |
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| 5,196,183 Contrast agents for ultrasound imaging | 111 | 1991 | |
| 5,354,549 Iodinated esters | 73 | 1991 | |
| 5,569,449 Gaseous microparticles as ultrasound contrast agents | 85 | 1995 | |
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| 4,572,203 Contact agents for ultrasonic imaging | 251 | 1983 | |
| 4,718,433 Contrast agents for ultrasonic imaging | 238 | 1985 | |
| 4,774,958 Ultrasonic imaging agent and method of preparation | 227 | 1987 | |
|
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|||
| 5,425,366 Ultrasonic contrast agents for color Doppler imaging | 220 | 1993 | |
| 6,068,857 Microparticles containing active ingredients, agents containing these microparticles, their use for ultrasound-controlled release of active ingredients, as well as a process for their production | 51 | 1996 | |
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| 4,866,096 Stable fluorochemical aqueous emulsions | 67 | 1987 | |
| 4,895,876 Concentrated stable fluorochemical aqueous emulsions containing triglycerides | 56 | 1987 | |
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| 5,460,800 Labeled fluorocarbon compositions | 33 | 1994 | |
| 5,980,936 Multiple emulsions comprising a hydrophobic continuous phase | 21 | 1997 | |
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| 5,958,371 Site specific binding system, nuclear imaging compositions and methods | 28 | 1997 | |
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|||
| 4,310,505 Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances | 120 | 1979 | |
| 4,310,506 Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species | 133 | 1980 | |
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| 4,684,479 Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures | 174 | 1985 | |
| 5,215,680 Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles | 221 | 1990 | |
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| 4,775,522 NMR compositions for indirectly detecting a dissolved gas in an animal | 113 | 1985 | |
| 5,536,753 Stable perfluorocarbon and oil emulsions | 15 | 1990 | |
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| 5,137,928 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents | 142 | 1991 | |
| 5,190,982 Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents | 112 | 1992 | |
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| 4,981,692 Therapeutic treatment by intramammary infusion | 80 | 1987 | |
| 5,008,050 Extrusion technique for producing unilamellar vesicles | 136 | 1989 | |
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| 4,900,540 Lipisomes containing gas for ultrasound detection | 179 | 1983 | |
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Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Oct 26, 2016 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |