Medical devices incorporating deuterated rapamycin for controlled delivery thereof
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United States of America Patent
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Apr 26, 2005
Grant Date -
Jul 10, 2003
app pub date -
Nov 20, 2002
filing date -
Sep 5, 1997
priority date (Note) -
Expired
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Abstract
Deuterated rapamycin can be controllably introduced target locations within the patient's body by using an implantable medical device having a structure incorporated with a therapeutic agent comprising a deuterated rapamycin. Representative deuterated rapamycins include epi-7-deuteromthyl rapamycin, 7,43-d.sub.6 rapamycin, 7-deuteromethyl rapamycin and 31,42-d.sub.2 -rapamycin and isomers thereof, and mixtures thereof. The deuterated rapamycin can also be glycosylated.
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