Screening assays for agonists and antagonists of receptor activator of NF-.kappa.B
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United States of America Patent
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Apr 26, 2005
Grant Date -
Jul 4, 2002
app pub date -
Sep 20, 2001
filing date -
Sep 22, 2000
priority date (Note) -
Expired
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Abstract
The present invention provides methods for screening for a molecule that antagonizes or agonizes RANK activity. One aspect of the invention involves the growth of RANK responsive cells in semi-solid medium, wherein exposure to a RANK antagonist promotes colony formation. Other aspects of the invention rely on promoter/reporter constructs using RANK responsive promoters derived from the MMP-9 and TRAP genes. Additional aspects of the invention exploit the ability of RANK to activate c-src activity, F-actin ring formation and CaPO.sub.4 resorption.
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