Process for the preparation of 9-.beta.-anomeric nucleoside analogs
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United States of America Patent
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Apr 26, 2005
Grant Date -
Feb 26, 2004
app pub date -
Aug 21, 2002
filing date -
Aug 21, 2002
priority date (Note) -
Expired
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Abstract
A process for substantially enhancing the regio and stereoselective synthesis of 9-.beta.-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-.beta.-D- or L-purine nucleoside analogs were obtained. This regio and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs and in particular 2'-deoxy, 3'-deoxy, 2'-deoxy-2'-.beta.-fluoro and 2',3'-dideoxy-2'-.beta.-fluoro purine nucleoside analogs in high yield without virtually any formation of the 7-positional isomers. The compounds are drugs or intermediates to drugs.
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