Nitric oxide-releasing metallic medical devices
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United States of America Patent
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May 3, 2005
Grant Date -
Nov 15, 2001
app pub date -
May 25, 2001
filing date -
May 10, 2000
priority date (Note) -
Expired
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Abstract
Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.
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