Magnetic separation apparatus and methods

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United States of America Patent

PATENT NO 6890426
APP PUB NO 20040118757A1
SERIAL NO

10733829

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Abstract

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Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic capture structure may be on the transparent collection wall (5), magnets (3) create an externally-applied force for transporting magnetically responsive material toward the transparent collection wall (5). The magnetic capture structure comprises a plurality of ferromagnetic members and has a uniform or non-uniform spacing between adjacent members. There may be electrical conductor means supported on the transparent collection wall (5) for enabling electrical manipulation of the biological substances. The chamber has one compartment or a plurality of compartments with differing heights. The chamber may include a porous wall. The invention is also useful in conducting quantitative analysis and sample preparation in conjunction with automated cell enumeration techniques.

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Patent Owner(s)

Patent OwnerAddress
JANSSEN DIAGNOSTICS LLC700 US HIGHWAY 202 RARITAN NJ 08869

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dolan, Gerald Huntingdon Valley, PA 5 182
Terstappen, Leon W M M Huntingdon Valley, PA 41 2065

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