Hydrolyzable delivery system using cross-linked polymeric resins as vehicles

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United States of America Patent

PATENT NO 6890524
SERIAL NO

09647503

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Abstract

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This invention provides a method of preparing a polymeric delivery system for active ingredients. The delivery system is formed either by attaching the active ingredient to a linker through a hydrolyzable covalent bond, then forming a covalent bond between the linker and a portion of the subunits of a cross-linked polymer, or by attaching a linker to a portion of the subunits of a cross-linked polymer, then attaching the active ingredient to the polymer-linker combination through a hydrolyzable covalent bond. The invention also provides a delivery system comprising an active ingredient covalently bonded through a hydrolyzale covalent bond to a linker, which is in turn covalently bonded to a portion of subunits of a cross-linked polymer.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MONSANTO COMPANYST LOUIS, MO294

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Tremont, Samuel J Manchester, MO 53 314

Cited Art Landscape

Patent Info (Count) # Cites Year
 
EURAND AMERICA, INC. (1)
5275824 Therapeutic compositions with controlled release of medicaments supported on crosslinked polymers and coated with polymer films, and their preparation process 61 1990
 
Other [Check patent profile for assignment information] (1)
4921707 Proceeding for the production of pharmaceutical preparations of high gastric acid binding capacity, of retarded effect and of increased bioavailability 6 1988
 
SOLUTIA INC. (1)
5474767 Polyamines and method for preparation thereof 16 1993
 
MEDICAL COLLEGE OF OHIO (1)
4663308 Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract 76 1984
 
MONSANTO COMPANY (2)
* 5827925 Polymeric drug delivery system 21 1993
* 6096834 Hydrolyzable delivery system using crosslinked polymeric resins as vehicles 3 1998
 
AFFYMAX TECHNOLOGIES N.V. (1)
* 5607691 Compositions and methods for enhanced drug delivery 190 1995
 
PHARMACIA CORPORATION (1)
* 6471955 Ph-selective delivery system using crosslinked polymeric resins as vehicles 12 1998
 
BUFORD BIOMEDICAL, INC. (1)
* 5783214 Bio-erodible matrix for the controlled release of medicinals 37 1994
 
COLUMBIA LABORATORIES, INC. (1)
4615697 Bioadhesive compositions and methods of treatment therewith 244 1984
 
Smith Kline & French Laboratories Limited (1)
5169640 Pharmaceutical compositions 33 1989
* Cited By Examiner

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