Morpholino imaging and therapy
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United States of America Patent
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May 31, 2005
Grant Date -
Jan 2, 2003
app pub date -
Apr 1, 2002
filing date -
Mar 30, 2001
priority date (Note) -
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Abstract
The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein the targeting moiety selectively binds to a primary, target-specific binding site of the target site or to a substance produced by or associated with the target site; (b) optionally, a clearing agent; and (c) a second conjugate comprising a complementary Morpholino oligomer and a diagnostic agent or therapeutic agent. The method comprises administering (a), optionally (b), and (c) to a mammal.
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