Bacteria attenuated by a non-reverting mutation in each of the aroC, ompF and ompC genes, useful as vaccines
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United States of America Patent
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Jun 7, 2005
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Mar 25, 1999
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Mar 25, 1998
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Abstract
The invention provides a bacterium attenuated by a non-reverting mutation in each of the aroC gene, the ompF gene and the ompC gene. The bacterium is useful as a vaccine. The bacterium may, for example, be an attenuated strain of E. coli useful in vaccination against diarrhoea.
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