Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
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United States of America Patent
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Jun 14, 2005
Grant Date -
Mar 20, 2003
app pub date -
Nov 12, 2001
filing date -
Dec 24, 1991
priority date (Note) -
Expired
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Abstract
A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.
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