Synthetic methods and intermediates for triester oligonucleotides
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United States of America Patent
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Jul 19, 2005
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N/A
app pub date -
Jun 10, 1999
filing date -
Jun 11, 1998
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Expired
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Abstract
Methods for the preparation of oligonucleotides having bioreversible phosphate blocking groups are disclosed. In one aspect, the present invention provides compounds comprising a sequence of nucleotide units that includes a first segment having at least one internucleoside linkage of formula:
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