Methods of modulating pharmacokinetics of oligonucleotides
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United States of America Patent
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Jul 26, 2005
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N/A
app pub date -
Jan 28, 2002
filing date -
Jul 3, 2001
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Abstract
2′-O-(2-Methylthioethyl), has been incorporated into oligonucleotides and evaluated for antisense properties in comparison with the known 2′-O-(2-methoxyethyl) 2′-O-MOE modification. The 2′-O-MTE modified oligonucleotides exhibit improved binding to human serum albumin compared with the 2′-O-MOE modified oligonucleotides and maintain high binding affinity to target RNA.
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