Multiblock biodegradable hydrogels for drug delivery and tissue treatment
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United States of America Patent
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Aug 2, 2005
Grant Date -
Apr 15, 2004
app pub date -
Aug 27, 2003
filing date -
Jul 28, 1995
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Abstract
Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
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