Methods of activating a receptor using amphiphilic drug-oligomer conjugates
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United States of America Patent
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Aug 16, 2005
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Nov 19, 2003
filing date -
Aug 14, 1998
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Abstract
The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier ('BBB') and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugate comprises a therapeutic compound conjugated to an oligomer, wherein the oligomer comprises a lipophilic moiety coupled to a hydrophilic moiety. The conjugates of the invention further comprise therapeutic agents such as proteins, peptides, nucleosides, nucleotides, antiviral agents, antineoplastic agents, antibiotics, etc., and prodrugs, precursors, derivatives and intermediates thereof, chemically coupled to amphiphilic oligomers.
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