Method for preparing dexchlor tannate
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United States of America Patent
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-
Sep 6, 2005
Issued Date -
N/A
app pub date -
Aug 14, 2003
filing date -
Dec 14, 2001
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The invention pertains to a method for preparing dexchlorpheniramine ('dexchlor') tannate by reacting dexchlorpheniramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The dexchlorpheniramine free base may be obtained by reacting a commercially available dexchlorpheniramine salt such as dexchlorpheniramine maleate with a base such as aqueous sodium hydroxide. The resultant dexchlor tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.
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