Method for transferring nucleic acid into striated muscles
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United States of America Patent
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Sep 6, 2005
Grant Date -
Apr 17, 2003
app pub date -
Nov 7, 2001
filing date -
Jun 30, 1997
priority date (Note) -
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Abstract
The invention provides a method of transferring in vivo a molecule into a striated muscle cell. More specifically, a method of the invention comprises contacting in vivo a striated muscle cell with a molecule, and electrically stimulating the muscle cell with one or more unipolar pulses of an electric field intensity ranging from 1 to 800 V/cm2. In one embodiment, the molecule is a nucleic acid encoding a protein of interest. For example, the invention provides methods of promoting angiogenesis and hemostasis.
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