Bioartificial filtration device for filtering blood to mimic kidney function
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United States of America Patent
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Sep 13, 2005
Grant Date -
Jun 26, 2003
app pub date -
Dec 11, 2002
filing date -
Sep 30, 1996
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Abstract
A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Endothelial cells along with pericyte, vascular smooth muscle, and/or mesangial cells or any mesenchymally derived support cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure.
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