Method and apparatus for determining analyte concentration using phase and magnitude detection of a radiation transfer function
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United States of America Patent
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Sep 13, 2005
Grant Date -
May 6, 2004
app pub date -
Jun 6, 2003
filing date -
Mar 12, 1997
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method and apparatus of determining the analyte concentration of a test sample is described. A temperature gradient is introduced into the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. The modulation of the temperature gradient is controlled by a surface temperature modulation. A transfer function is determined that relates the surface temperature modulation to the modulation of the measured infrared radiation. Reference and analytical signals are detected. In the presence of the selected analyte, phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the sample.
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