T cell binding ligand peptides and method of inducing a cellular immune response
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United States of America Patent
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Oct 4, 2005
Grant Date -
Mar 25, 2004
app pub date -
May 24, 2001
filing date -
May 24, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention is based, in part, on the discovery that a modified version of Peptide G (Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO:2) obtained by replacing Asn with Asp to form Peptide G′ (Asp Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO: 1) overcomes the long range stabilization problem of the peptide conjugates and, quite surprisingly, also enhances the immune response, particularly the CD4 related (cell mediated) response, of conjugated peptides (L.E.A.P.S. constructs) as previously described.
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