Methods for identifying an agent that interacts with an active site of acyl carrier protein synthase or acyl carrier protein synthase complex
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United States of America Patent
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Oct 18, 2005
Grant Date -
Jul 18, 2002
app pub date -
Jan 25, 2001
filing date -
Jan 28, 2000
priority date (Note) -
Expired
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Abstract
This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.
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