US Patent No: 6,960,356

Number of patents in Portfolio can not be more than 2000

Orally administered drug delivery system providing temporal and spatial control

Stats

ATTORNEY / AGENT: (SPONSORED)
 

Importance

Loading Importance Indicators... loading....

Abstract

A pharmaceutical composition in the form of tablets or capsules provides a combination of temporal and spatial control of drug delivery to a patient for effective therapeutic results. The pharmaceutical composition comprises a drug, a gas generating component, a swelling agent, a viscolyzing agent, and optionally a gel forming polymer. The swelling agent belongs to a class of compounds known as superdisintegrants (e.g., cross-linked polyvinylpyrrolidone or sodium carboxymethylcellulose). The viscolyzing agent initially and the gel forming polymer thereafter form a hydrated gel matrix which entraps the gas, causing the tablet or capsule to be retained in the stomach or upper part of the small intestine (spatial control). At the same time, the hydrated gel matrix creates a tortuous diffusion path for the drug resulting in sustained release of the drug (temporal control). A preferred once daily ciprofloxacin formulation comprises 69.9% profloxacin base, 0.34% sodium alginate, 1.103% xanthan gum, 13.7% sodium bicarbonate, 12.1% cross-linked polyvinylpyrrolidone, and optionally other pharmaceutical xcipients, the formulation being in the form of a coated or uncoated tablet or capsule.

Loading the Abstract Image... loading....

First Claim

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
RANBAXY LABORATORIES LIMITEDNEW DELHI127

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Sen, Himadri Haryana, IN 34 84
Staniforth, John N Bath, GB 38 928
Talwar, Naresh New Delhi, IN 7 33

Cited Art

Patent Info (Count) # Cites Year
 
PENWEST PHARMACEUTICALS CO. (17)
4,994,276 Directly compressible sustained release excipient 69 1988
5,128,143 Sustained release excipient and tablet formulation 63 1990
5,135,757 Compressible sustained release solid dosage forms 43 1991
5,169,639 Controlled release verapamil tablets 33 1991
5,472,711 Agglomerated hydrophilic complexes with multi-phasic release characteristics 31 1992
5,478,574 Agglomerated hydrophilic complexes with multi-phasic release characteristics 27 1993
5,399,358 Sustained release formulations for 24 hour release of metroprolol 13 1993
5,399,359 Controlled release oxybutynin formulations 30 1994
5,399,362 Once-a-day metoprolol oral dosage form 19 1994
5,612,053 Controlled release insufflation carrier for medicaments 74 1995
5,512,297 Sustained release heterodisperse hydrogel systems for insoluble drugs 32 1995
5,554,387 Sustained release heterodisperse hydrogel systems for insoluble drugs 28 1995
5,773,025 Sustained release heterodisperse hydrogel systems--amorphous drugs 54 1996
5,667,801 Sustained release heterodisperse hydrogel systems for insoluble drugs 20 1996
5,670,168 Agglomerated hydrophilic complexes with multi-phasic release characteristics 22 1996
5,738,865 Controlled release insufflation carrier for medicaments 109 1996
5,846,563 Sustained release heterodisperse hydrogel systems for insoluble drugs 20 1997
 
Bayer Aktiengesellschaft (11)
4,412,986 Nifedipine-containing solid preparation composition 90 1981
4,562,069 Two-phase formulation 50 1984
4,588,726 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents 12 1985
4,659,603 Immunostimulating agents 8 1985
4,620,007 6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 34 1985
4,703,047 1-Cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents 5 1986
4,705,788 Novel antibacterial 7-amino-1(substituted cyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids 30 1986
4,980,353 1-aryl-4-quinolone-3-carboxylic acids 8 1986
4,772,605 Basic formulations of quinolonecarboxylic acids 13 1987
4,981,854 A-aryl-4-quinolone-3-carboxylic acids 3 1989
5,023,257 Intramuscular injection forms of gyrase inhibitors 10 1990
 
ALZA CORPORATION (8)
4,344,929 Method of delivering drug with aid of effervescent activity generated in environment of use 105 1981
4,434,153 Drug delivery system comprising a reservoir containing a plurality of tiny pills 101 1982
4,847,093 Dosage form with means for governing rate of gas formation 20 1986
4,786,503 Dosage form comprising parallel lamine 30 1987
4,931,285 Aqueous based pharmaceutical coating composition for dosage forms 27 1988
5,198,229 Self-retaining gastrointestinal delivery device 27 1991
5,534,263 Active agent dosage form comprising a matrix and at least two insoluble bands 21 1995
6,096,339 Dosage form, process of making and using same 30 1997
 
HAUSER-KUHRTS, INC. (6)
5,023,245 Improved niacin formulation 29 1989
5,096,714 Prolonged release drug tablet formulations 36 1989
5,118,510 Niacin drink mix formulation 18 1989
5,292,518 Prolonged-release drug tablet formulations 16 1992
5,445,826 Delivery system containing a gel-forming dietary fiber and a drug 20 1993
5,466,469 Granular drug delivery system 16 1994
 
PAUL ROYALTY FUND, L.P. (6)
4,839,177 System for the controlled-rate release of active substances 96 1986
5,464,633 Pharmaceutical tablets releasing the active substance after a definite period of time 69 1994
5,487,901 Process for preparing pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times 36 1994
5,738,874 Pharmaceutical tablet capable of liberating one or more drugs at different release rates 59 1995
5,650,169 Pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times 34 1995
5,780,057 Pharmaceutical tablet characterized by a showing high volume increase when coming into contact with biological fluids 63 1997
 
BAYER HEALTHCARE AG (5)
4,670,444 7-amino-1-cyclopropyl-4-oxo-1, 4-dihydro-quinoline-and naphthyridine-3-carboxylic acids and antibacterial agents containing these compounds 63 1984
4,705,789 Solutions of lactic acid salts of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids 8 1984
4,808,583 Solutions of lactic acid salts of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids 4 1987
4,892,741 Press coated DHP tablets 58 1988
4,957,922 Infusion solutions of 1-cyclopropyl-6-fluoro-1,4-di-hydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid 34 1989
 
E. R. Squibb & Sons, Inc. (5)
4,610,870 Controlled release formulation 71 1984
4,666,705 Controlled release formulation 40 1985
4,792,452 Controlled release formulation 88 1987
4,808,413 Pharmaceutical compositions in the form of beadlets and method 82 1987
5,169,638 Buoyant controlled release powder formulation 78 1991
 
Warner-Lambert Company (5)
4,695,463 Delivery system for active ingredients and preparation thereof 62 1985
4,977,154 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents 4 1986
4,803,205 Quinolones as antibacterial agents 6 1988
4,973,470 Sustained release pharmaceutical compositions 5 1989
5,256,662 Quinolinecarboxylic acid antibacterial agents 4 1992
 
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (4)
5,286,754 Pharmaceutical formulations of ciprofloxacin 9 1988
5,695,784 Flavor-masked pharmaceutical compositions 33 1994
5,651,985 Expandable pharmaceutical forms 15 1995
5,900,425 Pharmaceutical preparations having controlled release of active compound and processes for their preparation 18 1997
 
CIMA LABS INC. (4)
5,219,574 Magnesium carbonate and oil tableting aid and flavoring additive 31 1991
5,223,264 Pediatric effervescent dosage form 81 1991
5,178,878 Effervescent dosage form with microparticles 150 1992
5,503,846 Base coated acid particles and effervescent formulation incorporating same 52 1993
 
ELAN PHARMA INTERNATIONAL LIMITED (4)
5,051,262 Processes for the preparation of delayed action and programmed release pharmaceutical forms and medicaments obtained thereby 56 1986
5,015,479 Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine 38 1988
4,973,469 Drug delivery system 54 1989
5,128,142 Sustained release drug delivery system 42 1989
 
FOREST LABORATORIES, INC. (4)
4,369,172 Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose 212 1981
4,389,393 Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose 208 1982
4,540,566 Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose 64 1984
4,849,229 Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants 27 1988
 
BASF AKTIENGESELLSCHAFT (3)
5,741,519 The production of active substance compositions in the form of a solid solution of the active substance in a polymer matrix, and active substance compositions produced by this process 30 1996
6,001,391 Process for producing solid drug forms having at least two phases 49 1998
6,120,802 Method of producing multi-layer medicaments in solid form for oral or rectal administration 56 1998
 
BAYER ANIMAL HEALTH GMBH (3)
5,152,986 Preparation and use of ion exchange resins loaded with quinolonecarboxylic acid derivatives 13 1989
5,225,413 pH-neutral aqueous solutions of quinolone-carboxylic acids 4 1990
5,145,853 Bactericidal formulations for use in veterinary medicine 16 1991
 
ENDO PHARMACEUTICALS INC. (3)
5,455,046 Sustained release heterodisperse hydrogel systems for insoluble drugs 47 1993
5,662,933 Controlled release formulation (albuterol) 35 1995
5,958,456 Controlled release formulation (albuterol) 19 1997
 
MERCK & CO., INC. (3)
4,639,458 Tablet and formulation 13 1985
5,009,895 Sustained release with high and low viscosity HPMC 22 1990
5,288,507 Ibuprofen antacid combinations 12 1992
 
MYLAN PHARMACEUTICALS, INC. (3)
4,444,769 Antihypertensive diuretic combination composition and associated method 10 1983
4,526,777 Pharmaceutical combination composition and associated method 9 1984
4,547,498 Pharmaceutical combination composition and associated method 5 1984
 
PFIZER INC. (3)
5,002,772 Gastric retention system for controlled drug release 17 1988
5,443,843 Gastric retention system for controlled drug release 22 1990
5,697,922 Delivery device having encapsulated excipients 13 1995
 
ABBOTT LABORATORIES (2)
4,842,866 Slow release solid preparation 42 1987
5,084,276 Quinolone carboxylic acid compositions with polymeric additive to reduce vein irritation 6 1990
 
ADVANCED TECHNOLOGY PHARMACEUTICALS CORP. (2)
5,292,534 Sustained release composition and method utilizing xanthan gum and an active ingredient 29 1992
5,427,799 Sustained release composition and method utilizing xanthan gum and an active ingredient 20 1993
 
ALCON RESEARCH, LTD. (2)
5,631,004 Use of sustained release antibiotic compositions in ophthalmic surgical procedures 17 1993
6,174,524 Gelling ophthalmic compositions containing xanthan gum 23 1999
 
American Cyanamid Company (2)
4,992,449 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids 4 1990
5,283,065 Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form 67 1992
 
AMERICAN HOME PRODUCTS CORPORATION (2)
4,248,858 Sustained release pharmaceutical compositions 41 1979
4,309,405 Sustained release pharmaceutical compositions 67 1981
 
ENCINAL PHARMACEUTICAL INVESTMENTS, LLC (2)
6,120,803 Prolonged release active agent dosage form adapted for gastric retention 92 1998
6,077,538 Controlled release tablet compositions 11 1999
 
Ethical Pharmaceuticals Limited (2)
4,880,830 Slow release formulation 45 1987
5,145,683 Nifedipine-containing pharmaceutical compositions and process for the preparation thereof 36 1990
 
EURAND INTERNATIONAL S.P.A. (2)
5,047,248 Formulation for preparing sustained release drugs for oral administration 27 1989
5,306,506 Pharmaceutical composition for rapid suspension in water 46 1992
 
EURO-CELTIQUE S.A. (2)
4,867,985 Spheroids 64 1988
5,811,126 Controlled release matrix for pharmaceuticals 50 1995
 
FUJISAWA PHARMACEUTICAL CO., LTD. (2)
4,695,467 Sustained release tablet 57 1985
4,690,822 Novel drug carrier and pharmaceutical preparation comprising the same 42 1986
 
HOFFMANN-LA ROCHE INC. (2)
4,332,789 Pharmaceutical unit dosage forms 30 1977
4,424,235 Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor 32 1982
 
INSITE VISION INCORPORATED (2)
5,340,572 Alkaline ophthalmic suspensions 44 1993
5,474,764 Alkaline ophthalmic suspensions 14 1994
 
J. RETTENMAIER & SOEHNE GMBH + CO. KG (2)
5,585,115 Pharmaceutical excipient having improved compressability 54 1995
5,858,412 Sustained release formulations utilizing pharmaceutical excipient having improved compressibility with modified microcrystalline 57 1997
 
KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (2)
4,623,394 Gradually disintegrable molded article 33 1985
4,803,077 Process to prepare solid products containing oil-soluble substance 13 1987
 
MCNEIL-PPC, INC. (2)
5,296,233 Dual subcoated simulated capsule-like medicament 24 1992
5,807,580 Film coated tablet compositions having enhanced disintegration characteristics 21 1996
 
ORION-YHTYMA OY (2)
5,620,697 Method for preparing matrix-type pharmaceutical compositions through ultrasonic means to accomplish melting 21 1995
5,849,330 Controlled release pharmaceutical 16 1996
 
OTSUKA PHARMACEUTICAL CO., LTD. (2)
4,880,806 1-Cyclopropyl-6-fluoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives 12 1987
6,034,100 Method for inhibiting cytokine secretion 14 1995
 
POLICHEM S.A. (2)
5,788,987 Methods for treating early morning pathologies 24 1997
5,891,474 Time-specific controlled release dosage formulations and method of preparing same 34 1997
 
R.P. SCHERER CORPORATION (2)
4,800,083 Sustained release method and product 19 1986
5,888,540 Pharmaceutical products 3 1997
 
Smith Kline & French Laboratories Limited (2)
5,188,839 Pharmaceutical compositions of cimetidine 20 1989
4,996,222 Pharmaceutical formulations 19 1990
 
The Dow Chemical Company (2)
4,734,285 Sustained release compositions 36 1985
4,704,285 Sustained release compositions comprising hydroxypropyl cellulose ethers 57 1985
 
The Trustees of Columbia University in the City of New York (2)
5,019,096 Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same 502 1988
5,133,090 Antiviral glove 44 1990
 
Verex Laboratories, Inc. (2)
4,375,468 Constant order release aspirin composition and method of treating arthritis 32 1982
4,525,345 Constant order release, solid dosage indomethacin formulation and method of treating arthritis and other inflammatory conditions 25 1984
 
ABBVIE INC. (1)
5,705,190 Controlled release formulation for poorly soluble basic drugs 30 1995
 
Aktiebolaget Hassle (1)
4,942,040 Pharmaceutical preparation and a process for its preparation 37 1988
 
AMARIN DEVELOPMENT AB (1)
5,641,511 Granular drug delivery system 11 1995
 
ANDA SR PHARMACEUTICALS ICN. (1)
5,419,917 Controlled release hydrogel formulation 28 1994
 
ANDRX PHARMACEUTICALS, INC. (1)
5,728,402 Controlled release formulation of captopril or a prodrug of captopril 3 1994
 
APR APPLIED PHARMA RESEARCH SA (1)
5,681,583 Multilayered controlled-release oral solid pharmaceutical forms 59 1995
 
ASTRA AKTIEBOLAG (1)
5,419,918 Method for the manufacture of a controlled release solid unit dosage form 5 1993
 
BioAdvances LLC (1)
5,840,329 Pulsatile drug delivery system 132 1997
 
BIOSAT LIMITED (1)
5,051,263 Controlled-release formulations 32 1988
 
Boehringer Mannheim GmbH (1)
5,840,330 Process for the preparation of shaped, compressed controlled-release unit-dosage forms, and the compressed unit-dosage forms thus obtained 3 1994
 
BPSI HOLDINGS, INC. (1)
6,039,976 Enteric film coating compositions, method of coating therewith, and coated forms 19 1997
 
CAMBRIDGE SCIENTIFIC, INC. (1)
5,429,822 Biodegradable bursting release system 50 1992
 
Cheil Foods & Chemicals, Inc. (1)
5,484,785 Salts of a quinolone-carboxylic acid 2 1994
 
COLMAN PRODUCTS LIMITED (1)
4,652,446 Pharmaceutical compositions 2 1984
 
DAINIPPON PHARMACEUTICAL CO., LTD. (1)
5,082,669 Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked 26 1990
 
DepoMed Systems, Inc. (1)
5,007,790 Sustained-release oral drug dosage form 130 1989
 
DEVELOPMENT CENTER FOR BIOTECHNOLOGY (1)
6,183,777 Controlled release tacrine dosage form 8 1998
 
DR. RENTSCHLER GMBH & CO. MEDIZIN KG (1)
5,071,642 Dihydropyridine containing compositions 30 1987
 
DRUGTECH CORPORATION (1)
5,133,974 Extended release pharmaceutical formulations 202 1990
 
Duphar International Research B.V. (1)
5,219,575 Compositions with controlled zero-order delivery rate and method of preparing these compositions 16 1990
 
EISAI R&D MANAGEMENT CO., LTD. (1)
5,093,200 Multilayer sustained release granule 19 1988
 
ETHYPHARM (1)
5,464,632 Rapidly disintegratable multiparticular tablet 114 1994
 
Farmalyoc (1)
5,384,124 Solid porous unitary form comprising micro-particles and/or nano-particles, and its preparation 84 1992
 
FUISZ TECHNOLOGIES LTD. (1)
5,853,762 Delivery of controlled-release system(s) 12 1996
 
G. D. Searle & Co. (1)
5,232,704 Sustained release, bilayer buoyant dosage form 32 1990
 
GATX VENTURES, INC. (1)
5,582,837 Alkyl-substituted cellulose-based sustained-release oral drug dosage forms 83 1995
 
GLAXO GROUP LIMITED (1)
5,425,950 Controlled release pharmaceutical compositions 22 1994
 
GP PHARM, S.A. (1)
5,736,161 Pharmaceutical preparation for improving the bioavailability of drugs which are difficult to absorb and a procedure for obtaining it 24 1994
 
Health Products Development, Inc. (1)
4,613,497 Dry, water-foamable pharmaceutical compositions 41 1984
 
Hoechst Aktiengesellschaft (1)
4,542,011 Pharmaceutical compositions of xanthine derivatives tolerated by the stomach and process for their preparation 12 1984
 
Kabushiki Kaisha Daikin Seisakusho (1)
5,269,198 Liquid viscous damper 14 1992
 
KANEBO, LTD. (1)
4,765,990 Sustained-release nifedipine preparation 37 1987
 
KANSAI PAINT CO., LTD. (1)
5,616,388 Water repellent coating 6 1995
 
Key Pharmaceuticals, Inc. (1)
4,556,678 Sustained release propranolol tablet 32 1982
 
KNOLL PHARMACEUTICAL COMPANY (1)
4,308,251 Controlled release formulations of orally-active medicaments 54 1980
 
LTS LOHMANN THERAPIE-SYSTEME GMBH (1)
5,626,876 Floating system for oral therapy 7 1993
 
MEDA PHARMACEUTICALS INC. (1)
5,271,946 Controlled release azelastine-containing pharmaceutical compositions 30 1992
 
MERCK SHARP & DOHME CORP. (1)
5,366,738 Controlled release drug dispersion delivery device 44 1993
 
Minnesota Mining and Manufacturing Company (1)
5,225,201 Salsalate tablet 6 1991
 
NATIONAL BIOSOURCE, INC., A CORP. OF CA. (1)
4,965,252 Cholesterol-lowering combination compositions of guar gum and niacin 19 1988
 
NATIONSCREDIT COMMERCIAL CORPORATION, THROUGH ITS NATIONSCREDIT COMMERCIAL FUNDING DIVISION (1)
5,695,781 Sustained release formulation containing three different types of polymers 10 1995
 
NIKKEN CHEMICALS CO., LTD. (1)
4,692,337 Sustained release pharmaceutical tablet of theophylline and production process thereof 25 1984
 
NIPPON SHINYAKU CO., LTD. (1)
4,702,918 Pharmaceutical preparations and a method of manufacturing them 23 1985
 
Norwich Eaton Pharmaceuticals, Inc. (1)
4,798,725 Sustained release capsule 24 1986
 
NOVARTIS;CORPORATE INTELLECTUAL PROPERTY (1)
5,256,699 Dispersible tablet formulation of diclofenac acid free base 11 1992
 
Pentech Pharmaceuticals, Inc. (1)
5,624,677 Controlled release of drugs delivered by sublingual or buccal administration 28 1995
 
PURDUE PHARMA L.P. (1)
5,639,476 Controlled release formulations coated with aqueous dispersions of acrylic polymers 238 1995
 
PUTTER ELISABETH ANNA KLARA (1)
4,601,895 Delayed-action acetylsalicylic acid formulations for oral administration 9 1984
 
R.P. SCHERER TECHNOLOGIES, INC. (1)
5,858,409 Hydrolyzed cellulose granulations for pharmaceuticals 35 1996
 
RANBAXY LABORATORIES LIMITED (1)
5,728,401 Effervescent ranitidine formulations 4 1997
 
RECKITT & COLMAN PRODUCTS LIMITED (1)
4,829,056 Buccal tablet comprising etorphine or a salt thereof 14 1987
 
RECKITT BENCKISER HEALTHCARE (UK) LIMITED (1)
5,415,871 Therapeutic agents 29 1991
 
REID-ROWELL, INC., 640 TENTH STREET, ATLANTA, GEORGIA 30318, A GEORGIACORP. (1)
4,361,545 Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion 30 1981
 
Research Corporation (1)
4,717,713 Controlled release liquid pharmaceutical 35 1983
 
RHODIA INC. (1)
4,439,453 Directly compressible acetaminophen granulation 53 1982
 
Rhone-Poulenc Chimie (1)
6,221,393 Pharmaceutical compositions in the form of sustained-release tablets based on high molecular weight polysaccharide granules 4 1999
 
RHONE-POULENC RORER S.A. (1)
5,840,333 Process for the preparation of oral compositions containing quinolones 2 1996
 
Rhone-Poulenc Sante (1)
5,179,096 Therapeutic application of flouroquinolone derivatives 11 1990
 
SANOFI-AVENTIS SPA (1)
5,549,913 Multilayer matrix systems for the controlled release of active principles 17 1993
 
SHIONOGI EUROPE B.V. (1)
4,755,389 Chewable capsules 39 1986
 
SMADAR COHEN (1)
5,776,445 Ophthalmic delivery system 14 1996
 
SMITHKLINE BEECHAM P.L.C. (1)
5,597,844 Cimetidine granules coated with a partially hydrogenated vegetable oil 18 1995
 
St. John's University (1)
4,814,179 Floating sustained release therapeutic compositions 18 1987
 
SUOMEN SOKERI OY (1)
4,698,101 Binder-diluent composition and method 16 1985
 
TAKEDA GMBH (1)
5,997,903 Oral-administration forms of a medicament containing pantoprazol 19 1993
 
TANABE SEIYAKU CO., LTD. (1)
5,725,880 Pharmaceutical preparation controlled to release medicinal active ingredient at targeted site in intestinal tract 10 1995
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (1)
5,126,145 Controlled release tablet containing water soluble medicament 97 1990
 
Tech Trade Corp. (1)
4,590,062 Dry direct compression compositions for controlled release dosage forms 33 1984
 
Techmix, Inc. (1)
4,839,171 Composition for treating impaired lactation 5 1987
 
TEIJIN LIMITED (1)
4,777,033 Oral sustained release pharmaceutical preparation 24 1986
 
The United States of America as represented by the Secretary of Agriculture (1)
4,344,857 Encapsulation by entrapment 51 1980
 
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
5,773,019 Implantable controlled release device to deliver drugs directly to an internal portion of the body 100 1995
 
VALEANT INTERNATIONAL BERMUDA (1)
5,518,730 Biodegradable controlled release flash flow melt-spun delivery system 145 1992
 
VIRBAC CORPORATION (1)
5,683,722 Orally-administered dosage form for animals, preparation method therefor and uses thereof 11 1996
 
VITA CIENTIFICA (1)
5,786,363 Aqueous compositions containing ciprofloxacine, and related use 1 1997
 
WYETH (1)
5,759,579 Pharmaceutical suspension systems 30 1996
 
YAMANOUCHI EUROPE N.V. (1)
5,837,292 Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug 9 1996
 
YAMANOUCHI PHARMACEUTICAL CO., LTD. (1)
4,673,564 Sustained release pharmaceutical composition of solid medical material 38 1985
 
Zyna SA (1)
4,886,669 Galenical formulation 48 1987
 
Other [Check patent profile for assignment information] (10)
4,259,314 Method and composition for the preparation of controlled long-acting pharmaceuticals 107 1979
4,414,198 Rapidly disintegrable tablet composition and method 31 1982
4,762,702 Pharmaceutical preparation containing ibuprofen and a process for its preparation 26 1985
4,814,178 Floating sustained release therapeutic compositions 14 1987
4,904,699 Nifedipine concentrate stabilized against the influence of light and a process for its preparation 34 1987
4,978,661 Use of 6-halo-4-quinolone compounds and pharmaceutical compositions thereof for the preparation of a medicament for the therapeutical application in rheumatoid arthritis 2 1989
5,560,928 Nutritional and/or dietary composition and method of using the same 20 1995
5,686,095 Method of treating canker sores 1 1995
6,190,692 Time-specific controlled release capsule formulations and method of preparing same 24 1997
6,017,912 Topical fluoroquinolone antibiotics in an alcohol and acetone vehicle 6 1998

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
THE INVENTION SCIENCE FUND I, LLC (3)
8,303,573 Medical or veterinary digestive tract utilization systems and methods 0 2007
8,109,920 Medical or veterinary digestive tract utilization systems and methods 0 2007
8,333,754 Medical or veterinary digestive tract utilization systems and methods 0 2007
 
SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (2)
7,776,345 Gastric retention controlled drug delivery system 1 2002
8,012,496 Gastric retention controlled drug delivery system 0 2010

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 May 1, 2013
11.5 Year Payment $7400.00 $3700.00 $1850.00 May 1, 2017
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00