Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof

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United States of America Patent

PATENT NO 6972328
SERIAL NO

10702007

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Abstract

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The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-aggregation and reduced fluorescence quenching are obtained when the oligomers are used in various methods involving hybridization. Methods of synthesis, as well as novel synthetic precursors, are also provided.

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Patent Owner(s)

  • DRUG ROYALTY TRUST 9

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dempcy, Robert O Kirkland, WA 34 1106
Gall, Alexander A Bothell, WA 40 1111
Kutyavin, Igor V Bothell, WA 48 1687
Vermeulen, Nicolaas M J Woodinville, WA 33 1246

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