Chimaeric plant viruses with mucin peptides
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United States of America Patent
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Dec 27, 2005
Grant Date -
N/A
app pub date -
Sep 11, 2000
filing date -
Sep 9, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Mucin peptide epitopes are inserted into the coat protein of a plant virus (e.g., a comovirus such as CPMV) having a beta-barrel structure at an immunogenically effective site, such as in a loop connecting beta sheets or at/near the C-terminus. The resulting chimaeric virus particles are extremely immunogenic, giving better results than KLH conjugation and not requiring the addition of exogenous adjuvant. They are effective at mucosal surfaces, particularly when administered intranasally.
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