Emulsion vehicle for poorly soluble drugs
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United States of America Patent
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Jan 3, 2006
Grant Date -
Jun 5, 2003
app pub date -
May 17, 2002
filing date -
Jan 7, 1997
priority date (Note) -
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Abstract
An emulsion of α-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsion is PEGylated vitamin E. PEGylated α-tocopherol includes polyethylene glycol subunits attached by a succinic acid diester at the ring hydroxyl of vitamin E and serves as a primary surfactant, stabilizer and a secondary solvent in emulsions of α-tocopherol.
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