Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
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United States of America Patent
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Jan 3, 2006
Grant Date -
Oct 16, 2003
app pub date -
Dec 6, 2002
filing date -
Dec 7, 2001
priority date (Note) -
Expired
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Abstract
Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
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