Hot melt method for preparing diphenhydramine tannate
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United States of America Patent
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Feb 21, 2006
Issued Date -
N/A
app pub date -
Apr 16, 2004
filing date -
Dec 14, 2001
priority date (Note) -
Expired
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Abstract
The invention pertains to a method for preparing diphenhydramine tannate by reacting diphenhydramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The diphenhydramine free base may be obtained by reacting a commercially available diphenhydramine salt such as diphenhydramine maleate with a base such as aqueous sodium hydroxide. The resultant diphenhydramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.
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