Heterologous production of polyketides
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United States of America Patent
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Mar 14, 2006
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app pub date -
Oct 27, 2000
filing date -
Oct 27, 1999
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Abstract
Recombinant E. coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases and is not present in wild-type E. coli host cells.
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