US Patent No: 7,018,621
Number of patents in Portfolio can not be more than 2000
Delivery of rizatriptan or zolmitriptan through an inhalation route
Stats
-
Mar 28, 2006
Issued date -
Mar 3, 2004
filing date -
10/792,012
serial no -
Expired
status
Importance
Loading Importance Indicators...
Abstract
The present invention relates to the delivery of compounds for the treatment of migraine and headache through an inhalation route. Specifically, it relates to aerosols containing rizatriptan or zolmitriptan that are used in inhalation therapy. In a method aspect of the present invention, rizatriptan or zolmitriptan is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of rizatriptan or zolmitriptan on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering rizatriptan or zolmitriptan through an inhalation route is provided which comprises: a) a thin coating of a rizatriptan or zolmitriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
Loading the Abstract Image...
First Claim
Related Publications
Loading Related Publications...
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
|
|
|||
| 2003/0062,042 Aerosol generating method and device | 89 | 2001 | |
| 2003/0015,196 Aerosol forming device for use in inhalation therapy | 93 | 2002 | |
| 2003/0017,115 Delivery of drug esters through an inhalation route | 47 | 2002 | |
| 2003/0035,776 Delivery of aerosols containing small particles through an inhalation route | 53 | 2002 | |
| 2003/0209,240 Method and apparatus for vaporizing a compound | 85 | 2002 | |
| 2003/0007,933 Delivery of muscle relaxants through an inhalation route | 47 | 2002 | |
| 2003/0007,934 Delivery of stimulants through an inhalation route | 47 | 2002 | |
| 2003/0091,511 Delivery of diazepam through an inhalation route | 47 | 2002 | |
| 2003/0017,117 Delivery of analgesics through an inhalation route | 47 | 2002 | |
| 2003/0206,869 Delivery of antidepressants through an inhalation route | 49 | 2002 | |
| 2003/0017,116 Delivery of sedative-hypnotics through an inhalation route | 48 | 2002 | |
| 2003/0021,753 Delivery of antiemetics through an inhalation route | 47 | 2002 | |
| 2003/0005,924 Delivery of beta-blockers through an inhalation route | 47 | 2002 | |
| 2003/0012,740 Delivery of compounds for the treatment of parkinsons through an inhalation route | 47 | 2002 | |
| 2003/0017,118 Delivery of antipsychotics through an inhalation route | 48 | 2002 | |
| 2003/0021,754 Delivery of anti-migraine compounds through an inhalation route | 47 | 2002 | |
| 2003/0012,737 Delivery of diphenhydramine through an inhalation route | 47 | 2002 | |
| 2003/0015,189 Delivery of antihistamines through an inhalation route | 47 | 2002 | |
| 2003/0017,119 Delivery of opioids through an inhalation route | 50 | 2002 | |
| 2003/0032,638 Delivery of benzodiazepines through an inhalation route | 110 | 2002 | |
| 2003/0005,925 Delivery of rizatriptan or zolmitriptan through an inhalation route | 47 | 2002 | |
| 2003/0012,738 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route | 49 | 2002 | |
| 2003/0017,120 Delivery of erectile dysfunction drugs through an inhalation route | 47 | 2002 | |
| 2003/0021,755 Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route | 47 | 2002 | |
| 2003/0000,518 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route | 47 | 2002 | |
| 2003/0015,190 Delivery of compounds for the treatment of migraine through an inhalation route | 47 | 2002 | |
| 2003/0017,114 Delivery of physiologically active compounds through an inhalation route | 47 | 2002 | |
| 2003/0138,382 Delivery of caffeine through an inhalation route | 47 | 2002 | |
| 2004/0009,128 Delivery of drug amines through an inhalation route | 87 | 2003 | |
| 2004/0096,402 Delivery of aerosols containing small particles through an inhalation route | 90 | 2003 | |
| 2004/0105,818 Diuretic aerosols and methods of making and using them | 89 | 2003 | |
| 2004/0099,269 Drug condensation aerosols and kits | 51 | 2003 | |
| 2004/0101,481 Acute treatment of headache with phenothiazine antipsychotics | 82 | 2003 | |
| 2004/0105,819 Respiratory drug condensation aerosols and methods of making and using them | 85 | 2003 | |
| 2004/0126,326 Delivery of antidepressants through an inhalation route | 46 | 2003 | |
| 2004/0126,327 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route | 46 | 2003 | |
| 2004/0126,328 Delivery of compounds for the treatment of migraine through an inhalation route | 46 | 2003 | |
| 2004/0126,329 Delivery of analgesics through an inhalation route | 46 | 2003 | |
| 2004/0127,481 Delivery of anti-migraine compounds through an inhalation route | 45 | 2003 | |
| 2004/0127,490 Delivery of alprazolam, estazolam midazolam or triazolam through an inhalation route | 46 | 2003 | |
| 2004/0156,788 Delivery of erectile dysfunction drugs through an inhalation route | 46 | 2003 | |
| 2004/0156,789 Delivery of antihistamines through an inhalation route | 46 | 2003 | |
| 2004/0156,790 Delivery of drug esters through an inhalation route | 46 | 2003 | |
| 2004/0156,791 Delivery of antipsychotics through an inhalation route | 45 | 2003 | |
|
|
|||
| 4,708,151 Pipe with replaceable cartridge | 129 | 1986 | |
| 4,819,665 Aerosol delivery article | 107 | 1987 | |
| 4,924,883 Smoking article | 99 | 1987 | |
| 5,042,509 Method for making aerosol generating cartridge | 96 | 1987 | |
| 4,917,119 Drug delivery article | 125 | 1988 | |
| 4,941,483 Aerosol delivery article | 123 | 1989 | |
| 5,099,861 Aerosol delivery article | 117 | 1990 | |
| 5,135,009 Smokable article | 111 | 1990 | |
| 5,388,574 Aerosol delivery article | 135 | 1993 | |
|
|
|||
| 5,544,646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations | 191 | 1994 | |
| 5,957,124 Dynamic particle size control for aerosolized drug delivery | 162 | 1995 | |
| 5,694,919 Lockout device for controlled release of drug from patient-activated dispenser | 153 | 1995 | |
| 5,915,378 Creating an aerosolized formulation of insulin | 135 | 1995 | |
| 5,934,272 Device and method of creating aerosolized mist of respiratory drug | 173 | 1995 | |
| 5,960,792 Device for aerosolized delivery of peptide drugs | 165 | 1995 | |
| 5,735,263 Lockout device for controlled release of drug from patient-activated dispenser | 167 | 1996 | |
| 6,131,570 Temperature controlling device for aerosol drug delivery | 147 | 1998 | |
|
|
|||
| 5,060,671 Flavor generating article | 176 | 1989 | |
| 5,224,498 Electrically-powered heating element | 113 | 1991 | |
| 5,345,951 Smoking article | 94 | 1992 | |
| 5,666,977 Electrical smoking article using liquid tobacco flavor medium delivery system | 112 | 1994 | |
|
|
|||
| 5,743,251 Aerosol and a method and apparatus for generating an aerosol | 171 | 1996 | |
| 6,234,167 Aerosol generator and methods of making and using an aerosol generator | 154 | 1998 | |
| 6,701,922 Mouthpiece entrainment airflow control for aerosol generators | 95 | 2001 | |
|
|
|||
| 5,874,481 Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents | 94 | 1995 | |
| 6,041,777 Methods and apparatus for closed-circuit ventilation therapy | 166 | 1995 | |
|
|
|||
| 5,146,915 Anesthetic vaporizers | 98 | 1991 | |
| 5,592,934 Anaesthetic vaporizer | 97 | 1994 | |
|
|
|||
| 4,895,719 Method and apparatus for administering dehydrated liposomes by inhalation | 270 | 1987 | |
| 5,049,389 Novel liposome composition for the treatment of interstitial lung diseases | 154 | 1989 | |
|
|
|||
| 6,255,334 5HT 1 receptor agonists and metoclopramide for the treatment of migraine | 91 | 1999 | |
| 6,506,762 Certain alkylene diamine-substituted heterocycles | 97 | 2000 | |
|
|
|||
| 5,144,962 Flavor-delivery article | 156 | 1989 | |
| 5,649,554 Electrical lighter with a rotatable tobacco supply | 97 | 1995 | |
|
|
|||
| 5,855,913 Particles incorporating surfactants for pulmonary drug delivery | 215 | 1997 | |
| 6,136,295 Aerodynamically light particles for pulmonary drug delivery | 139 | 1998 | |
|
|
|||
| 6,095,153 Vaporization of volatile materials | 150 | 1998 | |
|
|
|||
| 5,366,770 Aerosol-plasma deposition of films for electronic cells | 115 | 1993 | |
|
|
|||
| 6,241,969 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery | 127 | 1998 | |
|
|
|||
| 6,051,566 Anti-reactive anti-asthmatic activity of non-steroidal anti-inflammatory drugs by inhalation | 90 | 1998 | |
|
|
|||
| 5,511,726 Nebulizer device | 163 | 1993 | |
|
|
|||
| 6,632,047 Heater element for use in an in situ thermal desorption soil remediation system | 103 | 2001 | |
|
|
|||
| 4,734,560 Vaporizing unit | 108 | 1987 | |
|
|
|||
| 6,514,482 Pulmonary delivery in treating disorders of the central nervous system | 123 | 2000 | |
|
|
|||
| 4,484,576 Apparatus for admixing liquid anesthetics and respiratory gas | 101 | 1983 | |
|
|
|||
| 2002/0117,175 Thermal vaporizing device for drug delivery | 86 | 2001 | |
|
|
|||
| 4,963,289 Method for producing monodisperse aerosols | 104 | 1989 | |
|
|
|||
| 2002/0176,841 Pharmaceutical formulations for sustained release | 92 | 2002 | |
|
|
|||
| 5,894,841 Dispenser | 245 | 1995 | |
|
|
|||
| 5,605,146 Method and an arrangement in connection with vaporizing an anaesthetic | 87 | 1994 | |
|
|
|||
| 5,456,247 Method for delivering drugs soluble in a vaporization vehicle | 90 | 1993 | |
|
|
|||
| 6,461,591 Medical aerosol formulations | 49 | 1999 | |
|
|
|||
| 6,155,268 Flavor-generating device | 119 | 1998 | |
|
|
|||
| 6,090,212 Substrate platform for a semiconductor substrate during rapid high temperature processing and method of supporting a substrate | 101 | 1997 | |
|
|
|||
| 5,564,442 Battery powered nicotine vaporizer | 127 | 1995 | |
|
|
|||
| 5,918,595 Method for vaporizing an anesthetic liquid and vaporizer operating according to the method | 92 | 1996 | |
|
|
|||
| 6,376,550 Pharmaceutical compositions containing tramadol for migraine | 39 | 1999 | |
|
|
|||
| 6,102,036 Breath activated inhaler | 133 | 1998 | |
|
|
|||
| 5,758,637 Liquid dispensing apparatus and methods | 170 | 1996 | |
|
|
|||
| 6,306,431 Apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds | 67 | 2000 | |
|
|
|||
| 5,738,865 Controlled release insufflation carrier for medicaments | 109 | 1996 | |
|
|
|||
| 4,566,451 Vapor inhalation device | 97 | 1983 | |
|
|
|||
| 5,993,805 Spray-dried microparticles and their use as therapeutic vehicles | 155 | 1995 | |
|
|
|||
| 5,840,246 Oil lamp with fragrance emanator | 164 | 1996 | |
|
|
|||
| 4,906,417 Humidifier | 123 | 1989 | |
|
|
|||
| 2002/0086,852 Method for treating respiratory disorders associated with pulmonary elastic fiber injury | 98 | 2001 | |
|
|
|||
| 5,767,117 Method for treating vascular headaches | 71 | 1994 | |
|
|
|||
| 4,735,217 Dosing device to provide vaporized medicament to the lungs as a fine aerosol | 191 | 1986 | |
|
|
|||
| 6,095,134 Methods and apparatus for fine particle formation | 151 | 1997 | |
|
|
|||
| 2002/0191,558 Distributed soft handoff among IP-based base stations | 2001 | ||
|
|
|||
| 6,158,431 Portable systems and methods for delivery of therapeutic material to the pulmonary system | 188 | 1998 | |
|
|
|||
| 6,772,756 Method and system for vaporization of a substance | 96 | 2002 | |
|
|
|||
| 2002/0037,828 Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation | 89 | 2001 | |
|
|
|||
| 4,853,517 Vaporizing unit | 104 | 1988 | |
|
|
|||
| RE30285 Spraying devices, in particular nebulizing devices | 112 | 1977 | |
| 4,303,083 Device for evaporation and inhalation of volatile compounds and medications | 159 | 1980 | |
| 4,474,191 Tar-free smoking devices | 145 | 1982 | |
| 4,848,374 Smoking device | 126 | 1988 | |
| 5,819,756 Smoking or inhalation device | 95 | 1996 | |
| 6,591,839 Filter material for reducing harmful substances in tobacco smoke | 107 | 2001 | |
| 2003/0004,142 Use of NSAIDs for prevention and treatment of cellular abnormalities of the lung or bronchial pathway | 96 | 2002 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Sep 28, 2013 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Sep 28, 2017 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |