Pharmaceutical composition containing an active agent in an amino acid copolymer structure
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United States of America Patent
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Mar 28, 2006
Grant Date -
Sep 12, 2002
app pub date -
Nov 8, 2001
filing date -
Mar 5, 1999
priority date (Note) -
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Abstract
A method of protecting a chemical compound from degradation comprising combining the chemical compound with an amino acid polymer. Disclosed are methods of combining chemical compounds with synthetic amino acid polymers for protection from degradation of the chemical compounds and to provide for controlled release of the compounds. A method is described for the selective release of drug substances from a synthetic amino acid polymer in the stomach or small intestine, utilizing pH-dependent changes in a higher order structure. A pharmaceutical composition comprising a drug substance that has been combined with an amino acid polymer and a pharmaceutically acceptable combination of excipients is disclosed. A cell culture media comprising a polypeptide containing glutamine that has been co-polymerized with an amino acid is described.
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