US Patent No: 7,022,330
Number of patents in Portfolio can not be more than 2000
Parenteral formulation for epothilone analogs
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Apr 4, 2006
Issued date -
Jan 17, 2002
filing date -
10/051,727
serial no -
In Force
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Abstract
A process for formulating certain epothilone analogs for parenteral administration is disclosed wherein the analog is dissolved in a mixture of at least 50% by volume tertiary-butanol in water, the mixture is lyophilized, the resulting lyophilized product is packaged in one vial with a sufficient amount of solvent comprising anhydrous ethanol and a suitable nonionic surfactant in a second vial. All steps are carried out with protection from light. In use, the contents of the second or diluent vial are added to the lyophilized product and mixed to constitute the epothilone analog and the resulting solution is diluted with a suitable diluent to produce a solution for intravenous injection containing the epothilone analog in a concentration of from about 0.1 mg/mL to about 0.9 mg/mL. A preferred surfactant is polyethoxylated castor oil and a preferred diluent is Lactated Ringer's Injection.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 6,365,749 Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs | 38 | 1998 | |
| 6,380,395 12, 13-cyclopropane epothilone derivatives | 23 | 1999 | |
| 6,399,638 12,13-modified epothilone derivatives | 30 | 1999 | |
| 6,780,620 Microbial transformation method for the preparation of an epothilone | 14 | 1999 | |
| 6,518,421 Process for the preparation of epothilone analogs | 27 | 2001 | |
| 6,689,802 Polymorphs of an epothilone analog | 19 | 2001 | |
| 6,670,384 Methods of administering epothilone analogs for the treatment of cancer | 21 | 2002 | |
| 6,576,651 Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones | 29 | 2002 | |
| 6,686,380 Treatment of refractory tumors using epothilone derivatives | 18 | 2002 | |
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| 6,194,181 Fermentative preparation process for and crystal forms of cytostatics | 42 | 1999 | |
| 6,387,927 Epothilone derivatives and their use as antitumor agents | 24 | 2001 | |
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| 5,977,163 Water soluble paclitaxel prodrugs | 156 | 1997 | |
| 6,441,025 Water soluble paclitaxel derivatives | 20 | 1998 | |
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| 4,950,432 Polyene microlide pre-liposomal powders | 17 | 1987 | |
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| 6,262,094 C-21 modified epothilones | 45 | 2000 | |
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| 2002/0045,609 Epothilone derivatives and methods for making and using the same | 19 | 2001 | |
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| 6,650,599 Method and apparatus for determining power level of laser beam in magneto-optical recording device | 2 | 2001 | |
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| 6,204,388 Synthesis of epothilones, intermediates thereto and analogues thereof | 56 | 1999 | |
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| 6,441,186 Epothilone analogs | 34 | 1997 | |
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| 6,211,412 Synthesis of epothilones | 49 | 1999 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Oct 4, 2013 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Oct 4, 2017 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |