Proteolysis targeting chimeric pharmaceutical
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United States of America Patent
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May 9, 2006
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N/A
app pub date -
Sep 10, 2001
filing date -
Sep 8, 2000
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Abstract
The present invention is based on the discovery of a composition that provides targeted ubiquitination. Specifically the composition contains an ubiquitin pathway protein binding moiety which recognizes an ubiquitin pathway protein and a targeting moiety which recognizes a target protein. In addition, the present invention provides libraries of compositions, where each composition contains an ubiquitin pathway protein binding moiety and a member of a molecular library. The libraries of the present invention can be used to identify proteins involved in a predetermined function of cells.
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