Process for making ondansetron and intermediates thereof

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United States of America Patent

PATENT NO 7041834
APP PUB NO 20040181076A1
SERIAL NO

10762552

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Abstract

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A process useful for making ondansetron that comprises reacting a carbazolone in a reaction mixture comprising a carbazolone of formula (2), a formaldehyde or precursor thereof, and an amine of formula (3) in a non-aqueous polar solvent and in the presence of a water binding agent. The reaction product(s) can be reacted with an amine of formula (5) to form ondansetron. The water binding agent can improve the yield and/or speed of the reaction ##STR00001##

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Patent Owner(s)

Patent OwnerAddress
SYNTHON BV6545 CM NIJMEGEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hesoun, Dusan Usti nad Labem, CZ 2 2
Hykl, Jiri Praha, CZ 2 3

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