ACE-2 modulating compounds and methods of use thereof
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United States of America Patent
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May 16, 2006
Issued Date -
N/A
app pub date -
Oct 31, 2001
filing date -
Apr 30, 1999
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Abstract
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I): Z-.LAMBDA. (I) Wherein Z is a zinc coordinating moiety and .LAMBDA. is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.
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