Methods for the inhibition of neointima formation
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United States of America Patent
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May 23, 2006
Grant Date -
Dec 19, 2002
app pub date -
Mar 11, 2002
filing date -
Apr 20, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Restenosis is inhibited through local delivery of anti-restenotic agents including angiotensin converting enzyme inhibitors; nicotine receptor agonists, agents that increase concentrations of nitric oxide, anti-angiogenic agents, agonists of the TGF-beta receptor; death domain receptor ligands; and thrombin inhibitors. In one embodiment of the invention, the localized delivery is effected through the use of a stent modified for delivery of the agent at the site of injury from balloon angioplasty.
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