Labelled glutamine and lysine analogues
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United States of America Patent
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May 23, 2006
Grant Date -
N/A
app pub date -
May 14, 1999
filing date -
May 15, 1998
priority date (Note) -
Expired
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Abstract
Synthetic analogues of lysine and glutamine are provided which function as substrates for the fibrin-stabilising enzyme Factor XIIIa even when labelled with a detectable moiety. The use of suitable protecting groups provides compounds which possess reduced susceptibility to in vivo metabolism especially by peptidases, and are hence useful agents for the diagnosis of thrombosis, embolism, atherosclerosis, inflammation or cancer.
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