Pharmaceuticals for the imaging of angiogenic disorders
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United States of America Patent
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May 30, 2006
Grant Date -
Jan 5, 2006
app pub date -
Jul 18, 2003
filing date -
Mar 31, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention describes novel compounds of the formula: (Q).sub.d--L.sub.n--C.sub.h, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
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