US Patent No: 7,052,706
Number of patents in Portfolio can not be more than 2000
Control release formulation containing a hydrophobic material as the sustained release agent
Stats
-
May 30, 2006
Issued date -
Jun 10, 2002
filing date -
10/167,368
serial no -
In Force
status
Importance
Loading Importance Indicators...
Abstract
The present invention is directed to a sustained release pharmaceutical composition in oral dosage form consisting essentially of a pharmaceutically effective amount of a medicament and a hydrophobic material in the absence of a lactose or hydrophobic carbohydrate polymer, said medicament being present in an amount greater than about 25% of the pharmaceutical composition and having a water solubility greater than about 1 gram per 10 mL of water at 25.degree. C., said hydrophobic material having a melting point ranging from at least about 40.degree. C. to about 100.degree. C. at 1 atm pressure, and being present in an amount ranging from about 3% to about 20% by weight of the pharmaceutical composition and in an amount less than the of the medicament, and said hydrophobic material not being present in coating of said pharmaceutical composition; said pharmaceutical composition being prepared by direct compression in the absence of or melting the hydrophobic material or the use of high shear mixer. The present invention is also directed to a method of preparing said pharmaceutical composition.
Loading the Abstract Image...
First Claim
Related Publications
Loading Related Publications...
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
|
|
|||
| 5,091,189 Controlled release dosage forms having a defined water content | 24 | 1991 | |
| 5,500,227 Immediate release tablet cores of insoluble drugs having sustained-release coating | 93 | 1993 | |
| 5,849,240 Method of preparing sustained release pharmaceutical compositions | 59 | 1996 | |
| 5,891,471 Pharmaceutical multiparticulates | 50 | 1996 | |
| 5,843,480 Controlled release diamorphine formulation | 41 | 1996 | |
| 5,879,705 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions | 54 | 1997 | |
| 5,965,163 Substained release compositions and a method of preparing pharmaceutical compositions | 58 | 1997 | |
|
|
|||
| 4,834,985 Controlled release pharmaceutical composition | 160 | 1987 | |
| 5,273,760 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer | 124 | 1991 | |
| 5,472,712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose | 109 | 1993 | |
| 5,958,459 Opioid formulations having extended controlled released | 51 | 1995 | |
| 5,681,585 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer | 56 | 1996 | |
|
|
|||
| 4,252,786 Controlled release tablet | 45 | 1979 | |
| 4,610,870 Controlled release formulation | 71 | 1984 | |
| 4,756,911 Controlled release formulation | 74 | 1986 | |
|
|
|||
| 4,634,587 Sustained release quinidine dosage form | 18 | 1984 | |
| 4,587,118 Dry sustained release theophylline oral formulation | 41 | 1984 | |
|
|
|||
| 5,376,384 Delayed, sustained-release pharmaceutical preparation | 35 | 1992 | |
| 5,478,573 Delayed, sustained-release propranolol pharmaceutical preparation | 25 | 1994 | |
|
|
|||
| 5,464,633 Pharmaceutical tablets releasing the active substance after a definite period of time | 69 | 1994 | |
| 5,650,169 Pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times | 33 | 1995 | |
|
|
|||
| 5,690,959 Pharmaceutical thermal infusion process | 13 | 1995 | |
| 5,824,344 Pharmaceutical thermal infusion granules | 4 | 1995 | |
|
|
|||
| 5,126,145 Controlled release tablet containing water soluble medicament | 96 | 1990 | |
| 5,268,181 Method of using niacin to control nocturnal cholesterol synthesis | 17 | 1992 | |
|
|
|||
| 4,248,857 Sustained release pharmaceutical compositions | 43 | 1979 | |
|
|
|||
| 5,651,984 Controlled release potassium tablet | 7 | 1995 | |
|
|
|||
| 6,039,974 Pharmaceutical composition for combination of piperidinoalkanol-decongestant | 15 | 1998 | |
|
|
|||
| 5,169,645 Directly compressible granules having improved flow properties | 81 | 1989 | |
|
|
|||
| 4,898,737 Controlled absorption pharmaceutical composition | 11 | 1988 | |
|
|
|||
| 6,379,700 Process for manufacturing tablets for the sustained release of active principle(s) | 23 | 2000 | |
|
|
|||
| 4,199,585 Method and composition for the therapy of cerebral circulatory diseases | 1 | 1978 | |
|
|
|||
| 5,591,452 Controlled release formulation | 50 | 1994 | |
|
|
|||
| 4,692,337 Sustained release pharmaceutical tablet of theophylline and production process thereof | 25 | 1984 | |
|
|
|||
| 5,700,410 Method of manufacturing wax matrices | 27 | 1995 | |
|
|
|||
| 4,752,470 Controlled release indomethacin | 46 | 1986 | |
|
|
|||
| 4,713,626 Operational amplifier utilizing JFET followers | 1 | 1986 | |
|
|
|||
| 5,023,089 Sustained-release preparations and the process thereof | 44 | 1989 | |
|
|
|||
| 5,213,811 Oral sustained-release drug compositions | 20 | 1991 | |
|
|
|||
| 4,235,870 Slow release pharmaceutical compositions | 16 | 1975 | |
|
|
|||
| 5,456,920 Uncoated tablets and method of producing the same | 27 | 1994 | |
|
|
|||
| 4,590,062 Dry direct compression compositions for controlled release dosage forms | 33 | 1984 | |
|
|
|||
| 4,375,468 Constant order release aspirin composition and method of treating arthritis | 32 | 1982 | |
|
|
|||
| 4,789,549 Sustained release dosage forms | 25 | 1987 | |
|
|
|||
| 4,443,428 Extended action controlled release compositions | 53 | 1982 | |
| 4,800,084 Pharmaceutical product in the form of a pellet with continuous, delayed medicament substance emission | 23 | 1987 | |
| 4,882,167 Dry direct compression compositions for controlled release dosage forms | 62 | 1987 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Nov 30, 2013 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Nov 30, 2017 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |