Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
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United States of America Patent
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May 30, 2006
Grant Date -
Sep 30, 2004
app pub date -
Dec 15, 2003
filing date -
Dec 19, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Indazole compounds that modulate and/or inhibit the ophthalmic diseases and the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating ophthalmic diseases and cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
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