Locked nucleic acid containing heteropolymers and related methods
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United States of America Patent
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May 30, 2006
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app pub date -
Jun 10, 2002
filing date -
Jun 12, 2001
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Abstract
The present invention relates to methods of replacing nucleotides in target nucleic acid sequences using DNA-LNA chimeras. The method of the present invention provides for replacing a first nucleotide in a target sequence by exposing the target sequence to a DNA-LNA heteropolymer and thereby replacing the first nucleotide with a second nucleotide. The invention also features the DNA-LNA chimeras themselves as well as methods of making them.
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