Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
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United States of America Patent
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May 30, 2006
Grant Date -
Dec 19, 2002
app pub date -
Aug 8, 2002
filing date -
Mar 25, 1999
priority date (Note) -
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Abstract
A method for delivery of an agent to a cell using electroporation is disclosed. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.
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