Hydrolytically degradable carbamate derivatives of poly(ethylene glycol)
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United States of America Patent
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Jun 13, 2006
Grant Date -
Jul 7, 2005
app pub date -
Jan 10, 2005
filing date -
Dec 23, 1999
priority date (Note) -
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Abstract
Poly(ethylene glycol) carbamate derivatives useful as water-soluble prodrugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the drug at a controllable rate as the gel degrades.
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