Modular targeted liposomal delivery system
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United States of America Patent
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Jun 13, 2006
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N/A
app pub date -
Nov 17, 2000
filing date -
Nov 24, 1999
priority date (Note) -
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Abstract
A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound to the lipid bilayer, and the targeting moiety is covalently bound to the linking moiety. The liposome may also include a stabilizing moiety interposed between the linking and targeting moieties, and covalently bound to both. Alternatively, the stabilizing and targeting moieties may be covalently bound to separate linking moieties, the linking moieties being electrostatically bound to the lipid bilayer.
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